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Article

Candida albicans GRX2, encoding a putative glutaredoxin, is required for virulence in a murine model.

Genetics and molecular research : GMR - 5 Oct 2007

Chaves G M, Bates S, Maccallum D M, Odds F C

Abstract excerpt

Resistance of Candida albicans to reactive oxygen species is thought to enhance its virulence in mammalian hosts. Genes such as SOD1, which encodes the anti-oxidant, superoxide dismutase, are known virulence factors. We disrupted the gene GRX2, which encodes a putative glutathione reductase (glutaredoxin) in C. albicans, and we compared the mutant with an sod1Deltamutant. In vitro, the grx2Deltastrain, but not...

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Identifiers

PMID: 18273798

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SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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