Article
Functional analysis of the superoxide dismutase family in Aspergillus fumigatus.
Molecular microbiology - 1 Feb 2010
Lambou Karine, Lamarre Claude, Beau Rémi, Dufour Nicolas, Latge Jean-Paul
Abstract excerpt
Reactive oxidant species produced by phagocytes have been reported as being involved in the killing of Aspergillus fumigatus. Fungal superoxide dismutases (SODs) that detoxify superoxide anions could be putative virulence factors for this opportunistic pathogen. Four genes encoding putative Sods have been identified in the A. fumigatus genome: a cytoplasmic Cu/ZnSOD (AfSod1p), a mitochondrial MnSOD (AfSod2p), a...
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