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Polyglutamine Diseases: Where does Toxicity Come from? What is Toxicity? Where are We Going?

21 Apr 2010

Abstract excerpt

Although the genetic basis of polyglutamine diseases has been recognized for 20 years, their molecular basis is still unclear. We have no therapeutic strategies for these intractable neurodegenerative disorders. To adequately treat patients, we must clarify the molecular basis of polyglutamine diseases. Three main issues address their molecular pathogenesis: whether the specific structure of expanded...

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PMID: 20410236
DOI: 10.1093/jmcb/mjq005

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