Article
Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model.
Circulation - 18 Jan 2005
Silva Guilherme V, Litovsky Silvio, Assad Joao A R, Sousa Andre L S, Martin Bradley J, Vela Deborah, Coulter Stephanie C, Lin Jing, Ober Judy, Vaughn William K, Branco Rodrigo V C, Oliveira Edie M, He Rumin, Geng Yong-Jian, Willerson James T, Perin Emerson C
Abstract excerpt
BACKGROUND: Bone marrow-derived stem cells are under investigation as a treatment for ischemic heart disease. Mesenchymal stem cells (MSCs) have been used preferentially in the acute ischemia model; data in the chronic ischemia model are lacking. METHODS AND RESULTS: Twelve dogs underwent ameroid constrictor placement. Thirty days later, they received intramyocardial injections of either MSCs (100x10(6) MSCs/10...
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