Autologous mesenchymal stem cells produce concordant improvements in regional function, tissue perfusion, and fibrotic burden when administered to patients undergoing coronary artery bypass grafting: The Prospective Randomized Study of Mesenchymal Stem Cell Therapy in Patients Undergoing Cardiac Surgery (PROMETHEUS) trial.

doi:10.1161/CIRCRESAHA.114.303180

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Autologous mesenchymal stem cells produce concordant improvements in regional function, tissue perfusion, and fibrotic burden when administered to patients undergoing coronary artery bypass grafting: The Prospective Randomized Study of Mesenchymal Stem Cell Therapy in Patients Undergoing Cardiac Surgery (PROMETHEUS) trial.

Circulation research - 11 Apr 2014

Karantalis Vasileios, DiFede Darcy L, Gerstenblith Gary, Pham Si, Symes James, Zambrano Juan Pablo, Fishman Joel, Pattany Pradip, McNiece Ian, Conte John, Schulman Steven, Wu Katherine, Shah Ashish, Breton Elayne, Davis-Sproul Janice, Schwarz Richard, Feigenbaum Gary, Mushtaq Muzammil, Suncion Viky Y, Lardo Albert C, Borrello Ivan, Mendizabal Adam, Karas Tomer Z, Byrnes John, Lowery Maureen, Heldman Alan W, Hare Joshua M

Abstract excerpt

RATIONALE: Although accumulating data support the efficacy of intramyocardial cell-based therapy to improve left ventricular (LV) function in patients with chronic ischemic cardiomyopathy undergoing CABG, the underlying mechanism and impact of cell injection site remain controversial. Mesenchymal...

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PMID: 24565698
DOI: 10.1161/CIRCRESAHA.114.303180
PMCID: PMC4104798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24565698-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

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