Article
Mesenchymal progenitor cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a rat cellular cardiomyoplasty model.
Circulation - 9 Sept 2003
Davani Siamak, Marandin Aliette, Mersin Nursen, Royer Bernard, Kantelip Bernadette, Hervé Patrick, Etievent Joseph-Philippe, Kantelip Jean-Pierre
Abstract excerpt
BACKGROUND: Cellular cardiomyoplasty is a promising approach to improve postinfarcted cardiac function. The differentiation pathways of engrafted mesenchymal progenitor cells (MPCs) and their effects on the left ventricular function in a rat myocardial infarct heart model were analyzed. METHODS AND RESULTS: A ligation model of left coronary artery of Lewis rats was used. MPCs were isolated by bone marrow cell...
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