Article
Cord lining-mesenchymal stem cells graft supplemented with an omental flap induces myocardial revascularization and ameliorates cardiac dysfunction in a rat model of chronic ischemic heart failure.
Tissue engineering. Part A - 1 Jun 2013
Lilyanna Shera, Martinez Eliana C, Vu Thang D, Ling Lieng H, Gan Shu U, Tan Ai L, Phan Thang T, Kofidis Theo
Abstract excerpt
Myocardial restoration using tissue-engineered grafts to regenerate the ischemic myocardium offers improved donor cell retention, yet a limited cell survival resulting from poor vascularization needs to be addressed. A cell type derived from the subamnion, namely, cord-lining mesenchymal stem cells (CL-MSC), has recently been identified. Here we present a restorative strategy that combines a fibrin graft...
Topics
- Animals
- Cell Survival
- Chronic Disease
- Disease Models, Animal
- Heart Failure
- Heart Function Tests
- Heart Ventricles
- Hemodynamics
- Humans
- Mesenchymal Stem Cell Transplantation