Article
Cortical Bone Stem Cell Therapy Preserves Cardiac Structure and Function After Myocardial Infarction.
Circulation research - 10 Nov 2017
Sharp Thomas E, Schena Giana J, Hobby Alexander R, Starosta Timothy, Berretta Remus M, Wallner Markus, Borghetti Giulia, Gross Polina, Yu Daohai, Johnson Jaslyn, Feldsott Eric, Trappanese Danielle M, Toib Amir, Rabinowitz Joseph E, George Jon C, Kubo Hajime, Mohsin Sadia, Houser Steven R
Abstract excerpt
RATIONALE: Cortical bone stem cells (CBSCs) have been shown to reduce ventricular remodeling and improve cardiac function in a murine myocardial infarction (MI) model. These effects were superior to other stem cell types that have been used in recent early-stage clinical trials. However, CBSC efficacy has not been tested in a preclinical large animal model using approaches that could be applied to patients....
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