Coronary vein infusion of multipotent stromal cells from bone marrow preserves cardiac function in swine ischemic cardiomyopathy via enhanced neovascularization.

doi:10.1038/labinvest.2010.202

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Article

Coronary vein infusion of multipotent stromal cells from bone marrow preserves cardiac function in swine ischemic cardiomyopathy via enhanced neovascularization.

Laboratory investigation; a journal of technical methods and pathology - 1 Apr 2011

Sato Takatoshi, Iso Yoshitaka, Uyama Taro, Kawachi Keisuke, Wakabayashi Kohei, Omori Yasutoshi, Soda Teruko, Shoji Makoto, Koba Shinji, Yokoyama Shin-Ichiro, Fukuda Noboru, Saito Satoshi, Katagiri Takashi, Kobayashi Youichi, Takeyama Youichi, Umezawa Akihiro, Suzuki Hiroshi

Abstract excerpt

Few reports have examined the effects of adult bone marrow multipotent stromal cells (MSCs) on large animals, and no useful method has been established for MSC implantation. In this study, we investigate the effects of MSC infusion from the coronary vein in a swine model of chronic myocardial infarction (MI). MI was induced in domestic swine by placing beads in the left coronary artery. Bone marrow cells were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21283079
DOI: 10.1038/labinvest.2010.202

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