Article
Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis.
Arthritis and rheumatism - 1 Jun 2000
Griffiths M M, Wang J, Joe B, Dracheva S, Kawahito Y, Shepard J S, Reese V R, McCall-Vining S, Hashiramoto A, Cannon G W, Remmers E F, Wilder R L
Abstract excerpt
OBJECTIVE: Collagen-induced arthritis (CIA) is a polygenic model of experimentally induced autoimmunity and chronic joint inflammation. This study maps genetic loci that regulate CIA susceptibility in DA/Bkl (DA) and BN/SsNHsd (BN) rats. METHODS: Genome scans covering chromosomes 1-20 and interva...
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