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Article

The UIM domain of Hrs couples receptor sorting to vesicle formation.

Journal of cell science - 15 Oct 2003

Urbé Sylvie, Sachse Martin, Row Paula E, Preisinger Christian, Barr Francis A, Strous Ger, Klumperman Judith, Clague Michael J

Abstract excerpt

Hepatocyte growth factor regulated tyrosine kinase substrate (Hrs), a main component of the 'bilayered' clathrin coat on sorting endosomes, was originally identified as a substrate of activated tyrosine kinase receptors. We have analysed Hrs phosphorylation in response to epidermal growth factor (EGF) stimulation and show that the evolutionary conserved tyrosines Y329 and Y334 provide the principal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12953068
DOI: 10.1242/jcs.00723

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The UIM domain of Hrs couples receptor sorting to vesicle formation.PMID 12953068Read ↗

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