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STAM and Hrs Down-Regulate Ciliary TRP Receptors

21 Jun 2007

Abstract excerpt

Cilia are endowed with membrane receptors, channels, and signaling components whose localization and function must be tightly controlled. In primary cilia of mammalian kidney epithelia and sensory cilia of Caenorhabditis elegans neurons, polycystin-1 (PC1) and transient receptor polycystin-2 channel (TRPP2 or PC2), function together as a mechanosensory receptor-channel complex. Despite the importance of the...

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PMID: 17581863
DOI: 10.1091/mbc.e07-03-0239

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