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Article

Toll-like receptors 2 and 4 do not contribute to clearance of Chlamydophila pneumoniae in mice, but are necessary for the release of monokines.

Immunobiology - 1 Jan 2004

Mueller Markus, Postius Stefan, Thimm Jean G, Gueinzius Katja, Muehldorfer Inge, Hermann Corinna

Abstract excerpt

Activation of immune cells by Chlamydophila pneumoniae in vitro has been shown to be toll-like receptor (TLR2)-dependent, but TLR4 is also involved to a minor extent. To investigate the role of TLR2 and TLR4 in vivo, a murine model of C. pneumoniae infection was established. Mice were infected intranasally with a low inoculum of 106 C. pneumoniae elementary bodies (EB) and spreading of bacteria was monitored by...

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Identifiers

PMID: 15638128
DOI: 10.1016/j.imbio.2004.08.003

Genes

TLR2
TLR4

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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