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Article

PcpA Promotes Higher Levels of Infection and Modulates Recruitment of Myeloid-Derived Suppressor Cells during Pneumococcal Pneumonia.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2016

Walker Melissa M, Novak Lea, Widener Rebecca, Grubbs James Aaron, King Janice, Hale Joanetha Y, Ochs Martina M, Myers Lisa E, Briles David E, Deshane Jessy

Abstract excerpt

We used two different infection models to investigate the kinetics of the PcpA-dependent pneumococcal disease in mice. In a bacteremic pneumonia model, we observed a PcpA-dependent increase in bacterial burden in the lungs, blood, liver, bronchoalveolar lavage, and spleens of mice at 24 h postinfection. This PcpA-dependent effect on bacterial burden appeared earlier (within 12 h) in the focal pneumonia model,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26829988
DOI: 10.4049/jimmunol.1402518
PMCID: PMC4761482

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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