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Article

Mutations in the RNA polymerase III subunit Rpc11p that decrease RNA 3' cleavage activity increase 3'-terminal oligo(U) length and La-dependent tRNA processing.

Molecular and cellular biology - 1 Jan 2005

Huang Ying, Intine Robert V, Mozlin Amy, Hasson Samuel, Maraia Richard J

Abstract excerpt

Termination by RNA polymerase III (Pol III) produces RNAs whose 3' oligo(U) termini are bound by La protein, a chaperone that protects RNAs from 3' exonucleases and promotes their maturation. Multiple reports indicate that yeasts use La-dependent and -independent pathways for tRNA maturation, with defective pre-tRNAs being most sensitive to decay and most dependent on La for maturation and function. The Rpc11p...

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Identifiers

PMID: 15632064
DOI: 10.1128/MCB.25.2.621-636.2005
PMCID: PMC543423

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Source receipt: pubmed, retrieved 7 Sept 2026.

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