Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The translin-TRAX complex (C3PO) is a ribonuclease in tRNA processing.

Nature structural & molecular biology - 1 Aug 2012

Li Liande, Gu Weifeng, Liang Chunyang, Liu Qinghua, Mello Craig C, Liu Yi

Abstract excerpt

Conserved translin-TRAX complexes, also known as C3POs, have been implicated in many biological processes, but how they function remains unclear. Recently, C3PO was shown to be an endoRNase that promotes RNA interference (RNAi) in animal cells. Here, we show that C3PO does not play a significant role in RNAi in the filamentous fungus Neurospora crassa. Instead, the Neurospora C3PO functions as an RNase that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoribonucleases
Share to Gene Knockout Techniques
Share to Mice, 129 Strain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multiprotein Complexes

Share to Neurospora crassa

Share to RNA, Fungal

Share to RNA Processing, Post-Transcriptional

Share to RNA, Transfer

Source

Open in PubMed Open full text

Identifiers

PMID: 22773104
DOI: 10.1038/nsmb.2337
PMCID: PMC3414638

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The translin-TRAX complex (C3PO) is a ribonuclease in tRNA processing.PMID 22773104Read ↗

C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation.Semantic proximity Read ↗

The tRNA 3'-end processing enzyme tRNase Z2 contributes to chloroplast biogenesis in rice.Semantic proximity Read ↗

Reconstitution of the Human tRNA Splicing Endonuclease Complex: insight into the regulation of pre-tRNA cleavageSemantic proximity Read ↗

Transcriptome targets of the exosome complex in plants.Semantic proximity Read ↗

Arabidopsis encodes four tRNase Z enzymes.Semantic proximity Read ↗

Mutations in the RNA polymerase III subunit Rpc11p that decrease RNA 3' cleavage activity increase 3'-terminal oligo(U) length and La-dependent tRNA processing.Semantic proximity Read ↗

Pti1p and Ref2p found in association with the mRNA 3' end formation complex direct snoRNA maturation.Semantic proximity Read ↗

Diverse pathways generate microRNA-like RNAs and Dicer-independent small interfering RNAs in fungi.Semantic proximity Read ↗

RNA degradation by the plant RNA exosome involves both phosphorolytic and hydrolytic activities.Semantic proximity Read ↗

5'UTR Editing of the ribosomal protein UL3Z gene unveils its critical roles in pre-rRNA processing and global mRNA translation dynamics.Semantic proximity Read ↗

Biological functions of translesion synthesis proteins in vertebrates.Semantic proximity Read ↗

Extensive degradation of RNA precursors by the exosome in wild-type cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.