Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition.

The Journal of cell biology - 3 Jan 2005

Bachelder Robin E, Yoon Sang-Oh, Franci Clara, de Herreros Antonio García, Mercurio Arthur M

Abstract excerpt

We report that the activity of glycogen synthase kinase-3 (GSK-3) is necessary for the maintenance of the epithelial architecture. Pharmacological inhibition of its activity or reducing its expression using small interfering RNAs in normal breast and skin epithelial cells results in a reduction of E-cadherin expression and a more mesenchymal morphology, both of which are features associated with an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast
Share to Cadherins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Glycogen Synthase Kinase 3

Share to Mesoderm

Share to NF-kappa B

Share to RNA, Small Interfering

Share to Snail Family Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 15631989
DOI: 10.1083/jcb.200409067
PMCID: PMC2171685

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition.PMID 15631989Read ↗

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.Semantic proximity Read ↗

Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?Semantic proximity Read ↗

Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cellsSemantic proximity Read ↗

Glycogen synthase kinase-3β is a pivotal mediator of cancer invasion and resistance to therapy.Semantic proximity Read ↗

Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity-Diverse effects on cell growth, metabolism and cancer.Semantic proximity Read ↗

Expression analysis of E-cadherin, Slug and GSK3β in invasive ductal carcinoma of breastSemantic proximity Read ↗

Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor κB target genes and induction of apoptosis in chronic lymphocytic leukemia B cellsSemantic proximity Read ↗

Recent advances in understanding the cellular roles of GSK-3Semantic proximity Read ↗

Kinase-Inactive Glycogen Synthase Kinase 3β Promotes Wnt Signaling and Mammary TumorigenesisSemantic proximity Read ↗

The enzyme glycogen synthase kinase-3 is associated with specific forms of oncogenesis; what more do we need to know to achieve clinical benefit?Semantic proximity Read ↗

GSK3, a master switch regulating cell-fate specification and tumorigenesis.Semantic proximity Read ↗

Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.