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Article

Glycogen synthase kinase-3β is a pivotal mediator of cancer invasion and resistance to therapy.

Cancer science - 1 Oct 2016

Domoto Takahiro, Pyko Ilya V, Furuta Takuya, Miyashita Katsuyoshi, Uehara Masahiro, Shimasaki Takeo, Nakada Mitsutoshi, Minamoto Toshinari

Abstract excerpt

Tumor cell invasion and resistance to therapy are the most intractable biological characteristics of cancer and, therefore, the most challenging for current cancer research and treatment paradigms. Refractory cancers, including pancreatic cancer and glioblastoma, show an inextricable association between the highly invasive behavior of tumor cells and their resistance to chemotherapy, radiotherapy and targeted...

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Identifiers

PMID: 27486911
DOI: 10.1111/cas.13028
PMCID: PMC5084660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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