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Article

Checkpoint-dependent RNR induction promotes fork restart after replicative stress.

Scientific reports - 20 Jan 2015

Morafraile Esther C, Diffley John F X, Tercero José Antonio, Segurado Mónica

Abstract excerpt

The checkpoint kinase Rad53 is crucial to regulate DNA replication in the presence of replicative stress. Under conditions that interfere with the progression of replication forks, Rad53 prevents Exo1-dependent fork degradation. However, although EXO1 deletion avoids fork degradation in rad53 mutants, it does not suppress their sensitivity to the ribonucleotide reductase (RNR) inhibitor hydroxyurea (HU). In this...

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Share to Cell Cycle Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Replication

Share to Exodeoxyribonucleases

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Source

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Identifiers

PMID: 25601385
DOI: 10.1038/srep07886
PMCID: PMC4298733

Genes

EXO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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