Article
Limb reduction defects in endothelial nitric oxide synthase-deficient mice.
The American journal of physiology - 1 Dec 1998
Gregg A R, Schauer A, Shi O, Liu Z, Lee C G, O'Brien W E
Abstract excerpt
Nitric oxide synthases are a family of enzymes capable of converting L-arginine to L-citrulline with the subsequent release of nitric oxide (NO). NO has been shown to have multiple biologic effects depending on the isoform responsible for its production and its tissue of origin. Murine endothelia...
Topics
- Acetylcholine
- Animals
- Aorta
- Limb Deformities, Congenital
- Mice
- Mice, Knockout
- Nitric Oxide Synthase
- Nitric Oxide Synthase Type II
- Nitric Oxide Synthase Type III
- Phenotype
- Phenylephrine
- Vasoconstrictor Agents
- Vasodilator Agents