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Article

Limb reduction defects in endothelial nitric oxide synthase-deficient mice.

The American journal of physiology - 1 Dec 1998

Gregg A R, Schauer A, Shi O, Liu Z, Lee C G, O'Brien W E

Abstract excerpt

Nitric oxide synthases are a family of enzymes capable of converting L-arginine to L-citrulline with the subsequent release of nitric oxide (NO). NO has been shown to have multiple biologic effects depending on the isoform responsible for its production and its tissue of origin. Murine endothelial nitric oxide synthase (eNOS) is encoded by Nos3, located on mouse chromosome 5. NO produced from this isoform causes...

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PMID: 9843834
DOI: 10.1152/ajpheart.1998.275.6.H2319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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