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Article

Bcl-2 expression suppresses mismatch repair activity through inhibition of E2F transcriptional activity.

Nature cell biology - 1 Feb 2005

Youn Cha-Kyung, Cho Hyun-Ju, Kim Soo-Hyun, Kim Hong-Beum, Kim Mi-Hwa, Chang In-Youb, Lee Jung-Sup, Chung Myung-Hee, Hahm Kyung-Soo, You Ho Jin

Abstract excerpt

Bcl-2 stimulates mutagenesis after the exposure of cells to DNA-damaging agents. However, the biological mechanisms of Bcl-2-mediated mutagenesis have remained largely obscure. Here we demonstrate that the Bcl-2-mediated suppression of hMSH2 expression results in a reduced cellular capacity to repair mismatches. The pathway linking Bcl-2 expression to the suppression of mismatch repair (MMR) activity involves the...

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Identifiers

PMID: 15619620
DOI: 10.1038/ncb1215

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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