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Article

A novel role for the Bcl-2 protein family: specific suppression of the RAD51 recombination pathway.

The EMBO journal - 15 May 2001

Saintigny Y, Dumay A, Lambert S, Lopez B S

Abstract excerpt

The oncogenic role of Bcl-2 is generally attributed to its protective effect against apoptosis. Here, we show a novel role for Bcl-2: the specific inhibition of the conservative RAD51 recombination pathway. Bcl-2 or Bcl-X(L) overexpression inhibits UV-C-, gamma-ray- or mutant p53-induced homologous recombination (HR). Moreover, Bcl-2 recombination inhibition is independent of the role of p53 in G1 arrest. At an...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins c-bcl-2

Share to Rad51 Recombinase

Share to Recombination, Genetic

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Source

Open in PubMed Open full text

Identifiers

PMID: 11350949
DOI: 10.1093/emboj/20.10.2596
PMCID: PMC125251

Genes

RAD51

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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