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Article

Apoptotic function of human PMS2 compromised by the nonsynonymous single-nucleotide polymorphic variant R20Q.

Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 2008

Marinovic-Terzic Ivana, Yoshioka-Yamashita Atsuko, Shimodaira Hideki, Avdievich Elena, Hunton Irina C, Kolodner Richard D, Edelmann Winfried, Wang Jean Y J

Abstract excerpt

Mismatch repair (MMR) corrects replication errors during DNA synthesis. The mammalian MMR proteins also activate cell cycle checkpoints and apoptosis in response to persistent DNA damage. MMR-deficient cells are resistant to cisplatin, a DNA cross-linking agent used in chemotherapy, because of impaired activation of apoptotic pathways. It is shown that postmeiotic segregation 2 (PMS2), an MMR protein, is required...

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Source

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Identifiers

PMID: 18768816
DOI: 10.1073/pnas.0806435105
PMCID: PMC2528866

Genes

PMS2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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