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Article

Bcl2 impedes DNA mismatch repair by directly regulating the hMSH2-hMSH6 heterodimeric complex.

The Journal of biological chemistry - 23 Mar 2007

Hou Yongzhong, Gao Fengqin, Wang Qinhong, Zhao Jinfeng, Flagg Tammy, Zhang Yangde, Deng Xingming

Abstract excerpt

Bcl2 has been reported to suppress DNA mismatch repair (MMR) with promotion of mutagenesis, but the mechanism(s) is not fully understood. MutSalpha is the hMSH2-hMSH6 heterodimer that primarily functions to correct mutations that escape the proofreading activity of DNA polymerase. Here we have di...

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Source

Identifiers

PMID: 17259174
DOI: 10.1074/jbc.M608523200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17259174-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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