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Article

hMSH3 overexpression and cellular response to cytotoxic anticancer agents.

Carcinogenesis - 1 Aug 2001

Pepponi R, Graziani G, Falcinelli S, Vernole P, Levati L, Lacal P M, Pagani E, Bonmassar E, Jiricny J, D'Atri S

Abstract excerpt

Mutations or transcriptional silencing of mismatch repair genes have been linked with tumour cell resistance to O(6)-guanine methylating agents, 6-thioguanine, cisplatin, doxorubicin and etoposide. Recently, it has been demonstrated that overexpression of the MSH3 protein is associated with depletion of the mismatch binding factor MutSalpha, and then with a marked reduction in the efficiency of base/base mismatch...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11470740
DOI: 10.1093/carcin/22.8.1131

Genes

MSH3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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hMSH3 overexpression and cellular response to cytotoxic anticancer agents.PMID 11470740Read ↗

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