Article
Anti-apoptotic Bcl-2 proteins: structure, function and relevance for radiation biology
1 Jan 2002
Abstract excerpt
PURPOSE: Bcl-2 family members mediate anti-apoptotic signals in a wide variety of human cell systems. Despite its proven antiapoptotic function, several results indicate that overexpression of Bcl-2 is not clearly associated with increased radiation resistance in vitro or in vivo. The reasons for this obvious contradiction are not understood. MATERIALS AND METHODS: Current data on the function of Bcl-2 as an...
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