Article
A linkage study between the GABAA beta2 and GABAA gamma2 subunit genes and major psychoses.
CNS spectrums - 1 Jan 2005
Ambrósio Alda M, Kennedy James L, Macciardi Fabio, King Nicole, Azevedo Maria H, Oliveira Catarina R, Pato Carlos N
Abstract excerpt
BACKGROUND: Alterations of the gamma-aminobutyric acid (GABA) system have been implicated in the pathophysiology of major psychoses. OBJECTIVE: Restriction fragment length polymorphisms associated with the human gamma-aminobutyric acid type A (GABAA) beta2 and GABAA gamma2 subunit genes on chromosome 5q32-q35 were tested to determine whether they confer susceptibility to major psychoses. METHODS: Thirty-two...
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