Article
No evidence for an association between variants at the gamma-amino-n-butyric acid type A receptor beta2 locus and schizophrenia.
Psychiatric genetics - 1 Feb 2007
Jamra Rami Abou, Becker Tim, Klopp Norman, Dahdouh Faten, Schulze Thomas G, Gross Magdalena, Deschner Monika, Schmäl Christine, Illig Thomas, Rietschel Marcella, Propping Peter, Cichon Sven, Nöthen Markus M, Schumacher Johannes
Abstract excerpt
The alpha1/beta2/gamma2-containing heteropentamer is the most abundant gamma-amino-n-butyric acid type A receptor subtype in mammalian brains and the corresponding genes, the GABRA1, GABRB2, and GABRG2 genes, are located in chromosomal region 5q34 that several genome wide scans have implicated as a susceptibility region for schizophrenia. Given this positional and functional evidence, Lo et al. (Mol Psychiatry...
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