Article
Candidate gene study of eight GABAA receptor subunits in panic disorder.
The American journal of psychiatry - 1 Aug 1997
Crowe R R, Wang Z, Noyes R, Albrecht B E, Darlison M G, Bailey M E, Johnson K J, Zoëga T
Abstract excerpt
OBJECTIVE: gamma-Aminobutyric acid type A (GABAA) receptor subunit genes are candidate genes for panic disorder. Benzodiazepine agonists acting at this receptor can suppress panic attacks, and both inverse agonists and antagonists can precipitate them. The human GABAA receptor subtypes are composed of various combinations of 13 subunits, each encoded by a unique gene. The authors tested eight of these subunits in...
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