Candidate gene study of eight GABAA receptor subunits in panic disorder.

doi:10.1176/ajp.154.8.1096

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Article

Candidate gene study of eight GABAA receptor subunits in panic disorder.

The American journal of psychiatry - 1 Aug 1997

Crowe R R, Wang Z, Noyes R, Albrecht B E, Darlison M G, Bailey M E, Johnson K J, Zoëga T

Abstract excerpt

OBJECTIVE: gamma-Aminobutyric acid type A (GABAA) receptor subunit genes are candidate genes for panic disorder. Benzodiazepine agonists acting at this receptor can suppress panic attacks, and both inverse agonists and antagonists can precipitate them. The human GABAA receptor subtypes are compos...

Topics

Adult
Agoraphobia
Female
Genetic Heterogeneity
Genetic Linkage
Genetic Variation
Humans
Lod Score
Male
Middle Aged
Models, Genetic
Mutation
Panic Disorder
Pedigree
Phenotype
Polymorphism, Genetic
Receptors, GABA-A

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