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Article

Hedgehog signaling pathway: development of antagonists for cancer therapy.

Current oncology reports - 1 Mar 2008

Xie Jingwu

Abstract excerpt

The hedgehog pathway, initially discovered in Drosophila by two Nobel laureates, Dr. Eric Wieschaus and Dr. Christiane Nüsslein-Volhard, is a major regulator for cell differentiation, tissue polarity, and cell proliferation. Studies from many laboratories--including ours--reveal activation of this pathway in most basal cell carcinomas and nearly one third of extracutaneous human cancers, including...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18377823
DOI: 10.1007/s11912-008-0018-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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