Axon pathfinding and the floor plate factor Reissner's substance in wildtype, cyclops and one-eyed pinhead mutants of Danio rerio.

Abstract excerpt

The ventral median floor plate (FP) is a well-examined embryonic structure, which is involved in neuron differentiation and axon outgrowth. The FP of different vertebrates expresses the glycoprotein Reissner's substance (RS). This glycoprotein is also produced by the dorsal median subcommissural organ (SCO). We examined if the dorsal SCO and the ventral FP are interdependent for the expression of RS and looked...

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