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Article

Reissner fibre-induced urotensin signalling from cerebrospinal fluid-contacting neurons prevents scoliosis of the vertebrate spine.

Biology open - 14 May 2020

Lu Hao, Shagirova Aidana, Goggi Julian L, Yeo Hui Li, Roy Sudipto

Abstract excerpt

Reissner fibre (RF), discovered by the 19th-century German anatomist Ernst Reissner, is a filamentous structure present in cerebrospinal fluid (CSF). RF forms by aggregation of a glycoprotein called SCO-spondin (Sspo), but its function has remained enigmatic. Recent studies have shown that zebrafish sspo mutants develop a curved embryonic body axis. Zebrafish embryos with impaired cilia motility also develop...

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Identifiers

PMID: 32409296
DOI: 10.1242/bio.052027
PMCID: PMC7240301

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