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Article

Transbilayer phospholipid flipping regulates Cdc42p signaling during polarized cell growth via Rga GTPase-activating proteins.

Developmental cell - 1 Nov 2007

Saito Koji, Fujimura-Kamada Konomi, Hanamatsu Hisatoshi, Kato Utako, Umeda Masato, Kozminski Keith G, Tanaka Kazuma

Abstract excerpt

An important problem in polarized morphogenesis is how polarized transport of membrane vesicles is spatiotemporally regulated. Here, we report that a local change in the transbilayer phospholipid distribution of the plasma membrane regulates the axis of polarized growth. Type 4 P-type ATPases Lem3p-Dnf1p and -Dnf2p are putative heteromeric phospholipid flippases in budding yeast that are localized to polarized...

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Share to ATP-Binding Cassette Transporters
Share to cdc42 GTP-Binding Protein, Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to GTP-Binding Protein alpha Subunits, Gs

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Share to Phosphatidylethanolamines

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Source

Identifiers

PMID: 17981141
DOI: 10.1016/j.devcel.2007.09.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transbilayer phospholipid flipping regulates Cdc42p signaling during polarized cell growth via Rga GTPase-activating proteins.PMID 17981141Read ↗

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