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Article

Identification of the cytoplasmic domains of CXCR4 involved in Jak2 and STAT3 phosphorylation.

The Journal of biological chemistry - 25 Feb 2005

Ahr Barbara, Denizot Mélanie, Robert-Hebmann Véronique, Brelot Anne, Biard-Piechaczyk Martine

Abstract excerpt

The chemokine SDF-1alpha transduces G(i)-dependent and -independent signals through CXCR4. Activation of Jak2/STAT3, a G(i)-independent signaling pathway, which plays a major role in survival signals, is known to be activated after SDF-1alpha binding to CXCR4 but the domains of CXCR4 involved in this signaling remain unexplored. Using human embryonic kidney HEK-293 cells stably expressing wild-type or mutated...

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Share to Chemokine CXCL12
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15615703
DOI: 10.1074/jbc.M408481200

Genes

CXCR4
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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