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Article

Role of the intracellular domains of CXCR4 in SDF-1-mediated signaling.

Blood - 15 Jan 2003

Roland Joachim, Murphy Brendan J, Ahr Barbara, Robert-Hebmann Véronique, Delauzun Vincent, Nye Keith E, Devaux Christian, Biard-Piechaczyk Martine

Abstract excerpt

The CXCR4 chemokine receptor is a G(i) protein-coupled receptor that triggers multiple intracellular signals in response to stromal cell-derived factor 1 (SDF-1), including calcium mobilization and p44/42 extracellular signal-regulated kinases (ERK1/2). Transduced signals lead to cell chemotaxis and are terminated through receptor internalization depending on phosphorylation of the C terminus part of CXCR4....

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Share to Chemokine CXCL12

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemokines, CXC

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Share to GTP-Binding Protein alpha Subunits, Gi-Go

Share to Mitogen-Activated Protein Kinases

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Source

Identifiers

PMID: 12393663
DOI: 10.1182/blood-2002-03-0978

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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