Article
Intracellular domains of CXCR3 that mediate CXCL9, CXCL10, and CXCL11 function.
The Journal of biological chemistry - 16 Jul 2004
Colvin Richard A, Campanella Gabriele S V, Sun Jieti, Luster Andrew D
Abstract excerpt
The chemokine receptor CXCR3 is a G protein-coupled receptor found predominantly on T cells that is activated by three ligands as follows: CXCL9 (Mig), CXCL10 (IP-10), and CXCL11 (I-TAC). Previously, we have found that of the three ligands, CXCL11 is the most potent inducer of CXCR3 internalization and is the physiologic inducer of CXCR3 internalization after T cell contact with activated endothelial cells. We...
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