Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Separate elements are required for ligand-dependent and -independent internalization of metastatic potentiator CXCR4.

Cancer science - 1 Mar 2007

Futahashi Yuko, Komano Jun, Urano Emiko, Aoki Toru, Hamatake Makiko, Miyauchi Kosuke, Yoshida Takeshi, Koyanagi Yoshio, Matsuda Zene, Yamamoto Naoki

Abstract excerpt

The C-terminal cytoplasmic domain of the metastatic potentiator CXCR4 regulates its function and spatiotemporal expression. However, little is known about the mechanism underlying constitutive internalization of CXCR4 compared to internalization mediated by its ligand, stromal cell-derived factor-1 alpha (SDF-1alpha)/CXCL12. We established a system to analyze the role of the CXCR4 cytoplasmic tail in steady-state...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokine CXCL12
Share to Chemokines, CXC

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endocytosis

Share to Glioblastoma

Share to Green Fluorescent Proteins

Share to HeLa Cells

Share to Ligands

Share to Receptors, CXCR4

Source

Open in PubMed Open full text

Identifiers

PMID: 17270027
DOI: 10.1111/j.1349-7006.2007.00388.x
PMCID: PMC11158236

Genes

CXCR4
CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Separate elements are required for ligand-dependent and -independent internalization of metastatic potentiator CXCR4.PMID 17270027Read ↗

The negative charge of the 343 site is essential for maintaining physiological functions of CXCR4.Semantic proximity Read ↗

Enhanced function with decreased internalization of carboxy-terminus truncated CXCR4 responsible for WHIM syndromeSemantic proximity Read ↗

The complex nature of CXCR4 mutations in WHIM syndrome.Semantic proximity Read ↗

Functional expression of CXCR4 in S. cerevisiae: development of tools for mechanistic and pharmacologic studies.Semantic proximity Read ↗

Regulation of CXCR4 signalingSemantic proximity Read ↗

Reduced G protein signaling despite impaired internalization and β-arrestin recruitment in patients carrying a CXCR4Leu317fsX3 mutation causing WHIM syndrome.Semantic proximity Read ↗

Receptor activation and 2 distinct COOH-terminal motifs control G-CSF receptor distribution and internalization kinetics.Semantic proximity Read ↗

CXCR4: From Signaling to Clinical Applications in Neuroendocrine NeoplasmsSemantic proximity Read ↗

CXCR4 signaling in health and disease.Semantic proximity Read ↗

CXCR4 dimerization and beta-arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome.Semantic proximity Read ↗

Hierarchical organization of multi-site phosphorylation at the CXCR4 C terminus.Semantic proximity Read ↗

A membrane-proximal basic domain and cysteine cluster in the C-terminal tail of CCR5 constitute a bipartite motif critical for cell surface expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.