Simple birth-death-mutation models predict some-but not all-aspects of the experimental evolution of antibiotic resistance.

Abstract excerpt

Mathematical modelling of antibiotic resistance plays an important role in understanding the mechanisms of resistance emergence and spreading, testing the feasibility of new treatment protocols, and antimicrobial stewardship. However, many assumptions underlying some of the most commonly used mathematical models have not been rigorously tested experimentally. We verify whether one of these models - a...

Topics

• Mutation
• Anti-Bacterial Agents
• Drug Resistance, Bacterial
• Models, Genetic
• Evolution, Molecular
• Drug Resistance, Microbial