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Article

Experimental evolution as an efficient tool to dissect adaptive paths to antibiotic resistance.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Dec 2013

Jansen Gunther, Barbosa Camilo, Schulenburg Hinrich

Abstract excerpt

Antibiotic treatments increasingly fail due to rapid dissemination of drug resistance. Comparative genomics of clinical isolates highlights the role of de novo adaptive mutations and horizontal gene transfer (HGT) in the acquisition of resistance. Yet it cannot fully describe the selective pressures and evolutionary trajectories that yielded today's problematic strains. Experimental evolution offers a compelling...

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PMID: 24594007
DOI: 10.1016/j.drup.2014.02.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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