Article
Association of an aromatase TTTA repeat polymorphism with circulating estrogen, bone structure, and biochemistry in older women.
American journal of physiology. Endocrinology and metabolism - 1 May 2005
Dick I M, Devine A, Prince R L
Abstract excerpt
Osteoporosis is a disease that is strongly genetically determined. Aromatase converts androgens to estradiol in postmenopausal women, therefore polymorphisms of the gene for this enzyme may be associated with bone mass and fracture. We investigated the association of the TTTA microsatellite polymorphism in intron 4 of the aromatase (CYP19) gene with bone mineral density (BMD) and fracture in 1,257 women aged 70...
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