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Herpes simplex virus 1 inhibits phosphorylation of RNA polymerase II CTD serine-7

24 Sept 2024

Abstract excerpt

Transcriptional activity of RNA polymerase II (Pol II) is influenced by post-translational modifications of the C-terminal domain (CTD) of the largest Pol II subunit, RPB1. Herpes simplex virus type 1 (HSV-1) usurps the cellular transcriptional machinery during lytic infection to efficiently express viral mRNA and shut down host gene expression. The viral immediate-early protein ICP22 interferes with serine 2...

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PMID: 39316591
DOI: 10.1128/jvi.01178-24

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Herpes simplex virus 1 inhibits phosphorylation of RNA polymerase II CTD serine-7PMID 39316591Read ↗

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