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Article

High affinity RNA for mammalian initiation factor 4E interferes with mRNA-cap binding and inhibits translation.

RNA (New York, N.Y.) - 1 Jan 2005

Mochizuki Kiyotaka, Oguro Akihiro, Ohtsu Takashi, Sonenberg Nahum, Nakamura Yoshikazu

Abstract excerpt

The eukaryotic translation initiation factor 4F (eIF4F) consists of three polypeptides (eIF4A, eIF4G, and eIF4E) and is responsible for recruiting ribosomes to mRNA. eIF4E recognizes the mRNA 5'-cap structure (m7GpppN) and plays a pivotal role in control of translation initiation, which is the rate-limiting step in translation. Overexpression of eIF4E has a dramatic effect on cell growth and leads to oncogenic...

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Identifiers

PMID: 15611299
DOI: 10.1261/rna.7108205
PMCID: PMC1370693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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