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Article

Blocking eIF4E-eIF4G Interaction as a Strategy To Impair Coronavirus Replication

22 Apr 2011

Abstract excerpt

Coronaviruses are a family of enveloped single-stranded positive-sense RNA viruses causing respiratory, enteric, and neurologic diseases in mammals and fowl. Human coronaviruses are recognized to cause up to a third of common colds and are suspected to be involved in enteric and neurologic diseases. Coronavirus replication involves the generation of nested subgenomic mRNAs (sgmRNAs) with a common capped 5' leader...

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PMID: 21507972
DOI: 10.1128/jvi.00078-11

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