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Article

The impairment of CD8 responses limits the selection of escape mutations in acute hepatitis C virus infection.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2005

Urbani Simona, Amadei Barbara, Cariani Elisabetta, Fisicaro Paola, Orlandini Alessandra, Missale Gabriele, Ferrari Carlo

Abstract excerpt

Evasion from protective CD8 responses by mutations within immunodominant epitopes represents a potential strategy of HCV persistence. To investigate the pathogenetic relevance of this mechanism, a careful search for immunodominant CD8 epitopes was conducted in six patients with chronic evolution of HCV infection by analyzing their global CD8 response with a panel of overlapping synthetic peptides covering the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16301660
DOI: 10.4049/jimmunol.175.11.7519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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