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Article

The Drosophila U1-70K protein is required for viability, but its arginine-rich domain is dispensable.

Genetics - 1 Dec 2004

Salz Helen K, Mancebo Ricardo S Y, Nagengast Alexis A, Speck Olga, Psotka Mitchell, Mount Stephen M

Abstract excerpt

The conserved spliceosomal U1-70K protein is thought to play a key role in RNA splicing by linking the U1 snRNP particle to regulatory RNA-binding proteins. Although these protein interactions are mediated by repeating units rich in arginines and serines (RS domains) in vitro, tests of this domain's importance in intact multicellular organisms have not been carried out. Here we report a comprehensive genetic...

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Identifiers

PMID: 15611175
DOI: 10.1534/genetics.104.032532
PMCID: PMC1448718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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