Article
Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110.
Proceedings of the National Academy of Sciences of the United States of America - 17 Apr 2007
Trede Nikolaus S, Medenbach Jan, Damianov Andrey, Hung Lee-Hsueh, Weber Gerhard J, Paw Barry H, Zhou Yi, Hersey Candace, Zapata Agustin, Keefe Matthew, Barut Bruce A, Stuart Andrew B, Katz Tammisty, Amemiya Chris T, Zon Leonard I, Bindereif Albrecht
Abstract excerpt
The spliceosome cycle consists of assembly, catalysis, and recycling phases. Recycling of postspliceosomal U4 and U6 small nuclear ribonucleoproteins (snRNPs) requires p110/SART3, a general splicing factor. In this article, we report that the zebrafish earl grey (egy) mutation maps in the p110 gene and results in a phenotype characterized by thymus hypoplasia, other organ-specific defects, and death by 7 to 8...
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