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Article

Substitution of critical isoleucines in the KH domains of Drosophila fragile X protein results in partial loss-of-function phenotypes.

Genetics - 1 Mar 2007

Banerjee Paromita, Nayar Shweta, Hebbar Sarita, Fox Catherine F, Jacobs Michele C, Park Jae H, Fernandes Joyce J, Dockendorff Thomas C

Abstract excerpt

Fragile X mental retardation proteins (FMRP) are RNA-binding proteins that interact with a subset of cellular RNAs. Several RNA-binding domains have been identified in FMRP, but the contribution of these individual domains to FMRP function in an animal model is not well understood. In this study, we have generated flies with point mutations in the KH domains of the Drosophila melanogaster fragile X gene (dfmr1)...

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Identifiers

PMID: 17194772
DOI: 10.1534/genetics.106.068908
PMCID: PMC1840061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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