The conserved pre-mRNA splicing factor U2AF from Drosophila: requirement for viability.

doi:10.1126/science.7692602

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Article

The conserved pre-mRNA splicing factor U2AF from Drosophila: requirement for viability.

Science (New York, N.Y.) - 22 Oct 1993

Kanaar R, Roche S E, Beall E L, Green M R, Rio D C

Abstract excerpt

The large subunit of the human pre-messenger RNA splicing factor U2 small nuclear ribonucleoprotein auxiliary factor (hU2AF65) is required for spliceosome assembly in vitro. A complementary DNA clone encoding the large subunit of Drosophila U2AF (dU2AF50) has been isolated. The dU2AF50 protein is...

Topics

Amino Acid Sequence
Animals
Base Sequence
Conserved Sequence
DNA, Complementary
Drosophila melanogaster
Female
Gene Transfer Techniques
Genes, Insect
Genes, Lethal
In Situ Hybridization
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Nuclear Proteins

RNA

RNA Precursors

RNA Splicing

Source

Open in PubMed

Identifiers

PMID: 7692602
DOI: 10.1126/science.7692602

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7692602-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The conserved pre-mRNA splicing factor U2AF from Drosophila: requirement for viability.PMID 7692602Read ↗

Mutations in the small subunit of the Drosophila U2AF splicing factor cause lethality and developmental defects.Semantic proximity Read ↗

Genome-wide analysis reveals an unexpected function for the Drosophila splicing factor U2AF50 in the nuclear export of intronless mRNAs.Semantic proximity Read ↗

Molecular characterization and phylogeny of U2AF35 homologs in plants.Semantic proximity Read ↗

The Drosophila U2 snRNP protein U2A' has an essential function that is SNF/U2B" independent.Semantic proximity Read ↗

Mechanisms for U2AF to define 3' splice sites and regulate alternative splicing in the human genome.Semantic proximity Read ↗

Multiple developmental requirements of noisette, the Drosophila homolog of the U2 snRNP-associated polypeptide SP3a60.Semantic proximity Read ↗

Primary structure of the human splicing factor asf reveals similarities with drosophila regulatorsSemantic proximity Read ↗

Genomic mRNA profiling reveals compensatory mechanisms for the requirement of the essential splicing factor U2AF.Semantic proximity Read ↗

Identification and characterization of a yeast gene encoding the U2 small nuclear ribonucleoprotein particle B" protein.Semantic proximity Read ↗

A U1-U2 snRNP interaction network during intron definition.Semantic proximity Read ↗

Analysis of mutant phenotypes and splicing defects demonstrates functional collaboration between the large and small subunits of the essential splicing factor U2AF in vivo.Semantic proximity Read ↗

The conserved RNA recognition motif 3 of U2 snRNA auxiliary factor (U2AF 65) is essential in vivo but dispensable for activity in vitro.Semantic proximity Read ↗

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