Article
Contributions of the RAD51 N-terminal domain to BRCA2-RAD51 interaction.
Nucleic acids research - 1 Oct 2013
Subramanyam Shyamal, Jones William T, Spies Maria, Spies M Ashley
Abstract excerpt
RAD51 DNA strand exchange protein catalyzes the central step in homologous recombination, a cellular process fundamentally important for accurate repair of damaged chromosomes, preservation of the genetic integrity, restart of collapsed replication forks and telomere maintenance. BRCA2 protein, a product of the breast cancer susceptibility gene, is a key recombination mediator that interacts with RAD51 and...
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