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Article

Functional comparison of the endothelial nitric oxide synthase Glu298Asp polymorphic variants in human endothelial cells.

Pharmacogenetics - 1 Dec 2004

McDonald Denise M, Alp Nicholas J, Channon Keith M

Abstract excerpt

The G894T endothelial nitric oxide synthase (eNOS) polymorphism results in a Glu to Asp substitution at position 298. This position is located externally on the protein and as the regulation of eNOS is dependent on its subcellular localization and interaction with modulatory proteins, we aimed to address whether the substitution of Asp at 298 had any effect on these mechanisms. Initially, we developed a novel...

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PMID: 15608562
DOI: 10.1097/00008571-200412000-00006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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